TherapeuSonics

Core technology: Pressure-Modulated Shockwave Histotripsy

• Our core proprietary technology is a next-generation, non-invasive tissue fractionation platform based on pressure-modulated shockwave histotripsy that overcomes the limitations of conventional therapeutic ultrasound. It precisely targets and mechanically fractionates biological tissue using highly engineered ultrasound energy. 

• By utilising pressure-modulated shockwaves, our system generates a powerful and highly controllable cavitation phenomenon. This mechanism mechanically destroys the targeted tissue without causing damage to the surrounding normal tissue. 

• The lesion size can be controlled from small to large by adjusting the pressure modulation timing.

Global Intellectual Patents

TherapeuSonics holds exclusive rights to pressure-modulated shockwave histotripsy, the foundational technology for next-generation therapeutic ultrasound devices. 

• Apparatus and method for precise mechanical tissue ablation using pressure modulated focused ultrasound (KOR 10-2320038) Granted

• Cavitation based tissue removal device using focused ultrasound (KOR 10-2583983) Granted

• Focused ultrasound output device and output method capable of large-area, high-speed fragmentation of biological tissue (KOR-10-2025-0089069) Application

• Apparatus and method for precise mechanical tissue ablation using pressure modulated focused ultrasound (US 12053198B2) Granted

• Cavitation based tissue removal device using focused ultrasound (US 12251583B2) Granted

• Focused ultrasound output device and output method capable of large-area, high-speed fragmentation of biological tissue (PCT/016195) Application

SCI Papers on Pressure-Modulated Shockwave Histotripsy 

• Control of the dynamics of a boiling vapour bubble using pressure-modulated high intensity focused ultrasound without the shock scattering effect: A first proof-of-concept study. Ultrasonics Sonochemistry. (Impact Factor 9.3)

• Noninvasive mechanical destruction of liver tissue and tissue decellularisation by pressure-modulated shockwave histotripsy. Frontiers in Immunology. (Impact Factor 8.7)

• A parametric study of bubble dynamics and lesion formation in liver tissue phantom during pressure-modulated shockwave histotripsy. Scientific Reports. (Impact Factor 3.8)